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KMID : 0882420150880040424
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Korean Journal of Medicine
2015 Volume.88 No. 4 p.424 ~ p.429
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A Case of Hepatocellular Carcinoma in a Patient with Crohn’s Disease
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Jang Seung-Hyeon
Kim Jee-Hyun
Lee Jae-Woo
Lee June-Young
Cho Young-Youn
Choi Won-Mook
Jung Hyun-Chae
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Abstract
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Hepatocellular carcinomas (HCCs) in patients with Crohn’s disease (CD) without underlying chronic hepatitis or liver cirrhosis are extremely rare. Previously reported cases occurred in patients who had developed CD at a young age and had been treated with immunosuppressive agents long-term. We herein report the first case of HCC in a 34-year-old patient with CD in Korea. The patient was treated with azathioprine for 14 years and had undergone repeated surgeries for CD. During the follow-up period, the patient was hospitalized for colon perforation and pericolic abscess formation. Computed tomography showed a liver mass, and HCC was diagnosed based on liver biopsy. The patient underwent right hemicolectomy for colon perforation and transcatheter arterial chemoembolization followed by radiofrequency ablation for the HCC. The present case is similar to previously reported cases with the exception of the liver pathology findings, which exhibited neither primary sclerosing cholangitis nor focal hepatic glycogenolysis.
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KEYWORD
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Hepatocellular carcinoma, Crohn disease, Azathioprine, Infliximab
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